During an airline strike in Mexico, a group of stranded passengers decide to take a ship voyage back home to the United States. Unbeknownst to them however, are two more passengers aboard that ship--more specifically, man-eating bears!

Captain Jordan Wright (Kiefer Sutherland) and his squadron are on leave for the wedding of one of their own in Mexico. The celebration is interrupted by a murderous cartel, with tragic consequences. As Jordan leads survivors to safety, war erupts between his squad and the cartel, forcing him into a battle to save his men.

At Pittsburgh's Trauma Medical Center, Dr. Michael "Robby" Robinavitch (Noah Wyle) oversees a motley crew of med students, interns, and residents in the understaffed and overcrowded emergency department, affectionately referred to as "The Pitt."